The present study was conducted to investigate the impact of wastewater received from Savar Tannery Industrial Estate into the Dhaleshwari river through the present status of water quality and pollution level. The water samples were collected from five different points, outfalls of the wastewater generated in the industrial estate, during post-monsoon and dry season from October 2019 to February 2020 and analyzed for six physico-chemical parameters. The observed values of pH, electric conductivity (EC), total dissolved solids (TDS), turbidity, dissolved oxygen (DO) and biochemical oxygen demand (BOD) were temporally varied from 6.8-8.06, 505.44-1544.4 µS/cm, 162-495 mg/l, 10.06-27.12 NTU, 1.3-3.96 mg/l and 8.20-13.432 mg/l respectively. The results were compared with guideline values and previous studies that were performed on this river of late. The river water was found to be significantly polluted and unsuitable for aquatic organisms living in the water body due to the occurrence of high level of BOD. The necessity for long-term monitoring combined with further investigation involving other parameters is highlighted.